View abstract. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Multiple human studies have shown that Siberian rhubarb extract significantly reduces all 11 of the recognized menopausal symptoms. It appears to have some benefits for the treatment of menopause symptoms ( 26 ). Zhou, Y, Huang, Z, Huang, T, and et al. 2016 Jun;15(3):34-9. Phytother Res 2018;32(8):1450-8. What are the side effects of Rhapontic rhubarb? View abstract. The product can eliminate night sweats, so you have a more restful sleep. J Ethnopharmacol. Nippon Jinzo Gakkai Shi 1996;38(8):379-387. 2021;51(8):916-925. This list does not cover all possible side effects. Please read the full product reviews disclaimer, https://www.mayoclinic.org/diseases-conditions/menopause/in-depth/hormone-therapy/art-20046372, https://pubmed.ncbi.nlm.nih.gov/17935960/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837008/. What are the side effects of Rhapontic rhubarb? The benefits possibly derive from its antioxidant and anti-inflammatory properties [6]. Rhubarb stalks are best if harvested in spring and early summer, but they do not become toxic or poisonous in late summer. Greenway FL, Liu Z, Martin CK, et al. In a meta-analysis of studies with nearly 1,000 participants, Chinese herbal mixtures containing rhubarb, in addition to conventional medication, helped patients recover from strokes by reducing the severity of their post-stroke symptoms [47]. The effects of rhubarb alone remain obscure. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. Its active ingredient is rhapontic. 1996;109(1):35-37. It was given alongside conventional treatment [11]. View abstract. Qian GP. Related: 13 Quick And Effective Home Remedies For Constipation 2. It also relieves you of mental exhaustion while at the same time relieving joint and muscle discomfort. View abstract. View abstract. Forsch Komplementarmed Klass Naturheilkd 2001;8:373-82. full sun Grow rhubarb in full sun, in rich, lightly moist soil. Zhong.Xi.Yi.Jie.He.Za Zhi. 2020;44(6):1066-1078. The rhaponticin and desoxyrhaponticin mimic estrogen, and so theyre able to stimulate estrogen receptors. There is a report of kidney failure in someone who took a product containing rhubarb. Then all you have to do is click the Browse button and search for your receipt picture file. Copyrights 2003-2023 All Rights Reserved. Supplementation with 1 g/day of rhubarb normalized levels of BUN, creatinine, and other waste products in 48 patients [13]. View abstract. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. 1999;19(12):725-727. Cureus 2021;13(10):e18419. It may bring on mild side effects like stomach pain or a rash, and it isnt meant to be taken long term. [Application and mechanism of radix et rhizoma rhei in treating diseases of the digestive system]. What are the side effects of rhubarb? View abstract. Would you like email updates of new search results? All of our content is written by scientists and people with a strong science background. . Fu, D. C. and Yu, C. Y. Introduction Rhapontic Rhubarb Root extract Microcrystalline Cellulose Stearic Acid Silica Sodium Pros The product could help you ease the symptoms of menopause It might be able to reduce pain, anxiety, restlessness, and other commonly associated symptoms It could help you get through the episodes of hot flashes 1990;103(10):788-793. More recently, it was uncovered that Rhubarb can also alleviate symptoms of menopause and sepsis, a life-threatening response to infection [4, 5, 6, 7]. There are some known side effects of black cohosh and soy isoflavones, components (ingredients) of Estroven. Basu TK, Ooraikul B, and Garg M. The lipid-lowering effects of rhubarb stalk fiber: A new source of dietary fiber. These compounds are highly concentrated in the leaves, which should not be consumed [7]. If you want to try this product, youll have to purchase it from a third-party retailer. Peng, S. M., Wang, S. Z., and Zhao, J. P. [Effect of rhubarb on inflammatory cytokines and complements in patients with systemic inflammation reaction syndrome and its significance]. Li, T. [Rhubarb in the treatment of viral hepatitis and its mechanism of action]. Epub 2021 Apr 27. Rhubarb has the potential to boost liver function, reduce fatty liver, and improve bile flow alongside conventional treatments. In a clinical trial of 32 people with kidney inflammation, a rhubarb-containing Chinese herbal remedy (Decoction of Qingre Huoxue) added to steroidal anti-inflammatory drugs improved kidney function better than the drugs alone. Rehman H, Begum W, Anjum F, Tabasum H, Zahid S. Effect of rhubarb (Rheum emodi) in primary dysmenorrhoea: a single-blind randomized controlled trial. Radiotherapy for lung cancer can cause severe adverse effects. Please enable it to take advantage of the complete set of features! The anthraquinone laxatives. All four analyses noted that the examined studies had poor methodological quality [28, 36, 47, 25]. Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms. The health effects of the other forms of rhubarb have not been studied extensively. . 1993;13(5):286-8, 261-2. (Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(2):88-89. The benefits of Black Cohosh and Estroven consist in relieving symptoms related to menopause and while black cohosh is mainly involved in alleviating hot flashes and improving vasomotor functions, estroven has other wide arrays of benefits including the following: Reducing night sweats and hot flashes. It includes rhaponticin and desoxyrhaponticin, which are able to stimulate estrogen receptors. It has a yellow-orange hue, and in this case, its used to give the capsules this color. Rhubarb also contains fiber, which might help reduce cholesterol levels and affect stomach conditions. After 84 days, the rhubarb extract reduced menopausal symptoms by 60%. 2021 Apr-Jun;12(2):175-179. doi: 10.4103/japtr.JAPTR_324_20. 2006;30:1737-41. An official website of the United States government. 2004;24(12):1084-1086. View abstract. Effects of rhubarb tannins on renal function in rats with renal failure. Contact your doctor or pharmacist if you notice any other side effects. 2000;20(9):660-663. The leaves of Rhubarb are toxic and should not be consumed. Gut bacteria then break them down into active metabolites, which reduce the amount of water the colon reabsorbs. Acute Respiratory Distress Syndrome causes serious lung inflammation. Rhapontic rhubarb is used for many of the same reasons as black cohosh, and it's the active ingredient in the popular menopause supplement Estroven. Bethesda, MD 20894, Web Policies A Chinese herbal with rhubarb (Jiangzhuoqinggan) was as effective as the standard drug, irbesartan, at reducing both systolic and diastolic blood pressure [42]. Rhubarb has a laxative effect, but a study published in the Journal of Ethnopharmacology found that it also has antidiarrheal effects because of its tannin content. Abdominal pain and cramping Uterine contractions Nausea and vomiting Pregnancy can temporarily cause high blood pressure. Flax seeds also contain high amounts of phytoestrogens. The combination worked by constricting the blood vessels, increasing platelets, improving platelet clumping, and reducing bleeding time [34]. A review. 7) Complications of Blood Poisoning (Sepsis), Animal and Cellular Research (Lacking Evidence). Ali R, Irfan M, Akram U, et al. Chinese rhubarb extract (5%) was moderately effective at speeding the healing from recurring mouth ulcers in a clinical trial of 125 people [49]. 1996;11(1):186-190. Chinese rhubarb, which the majority of the studies used, is usually combined with other Chinese herbs and medicinal plants. Zhang, Z. J., Cheng, W. W., and Yang, Y. M. [Low-dose of processed rhubarb in preventing pregnancy induced hypertension]. Jonathan Ritter, PharmD, PhD (Pharmacology), Relieves menopausal symptoms and menstrual pain, Helps with sepsis and pesticide poisoning, Can cause diarrhea due to laxative effect, Various plant pigments (anthraquinone compounds such as, Laxative phenolic compounds (anthraquinone glycosides such as sennosides), Antioxidant phenolic compounds (catechins), Traditional Chinese Medicine combination remedies (most common). [Chinese Journal of Modern Developments in Traditional Medicine] 1991;11(7):392-6, 387. The site is secure. View abstract. The product relies solely on one active ingredient. 1993;13(2):71-3, 67. WebMD does not provide medical advice, diagnosis or treatment. View abstract. Am J Forensic Med Pathol. Research shows evidence for the effectiveness of this plant in treating menopause symptoms. This benefit of rhubarb is mainly due to the presence of dietary fibers in them. stones should also avoid rhubarb due to the oxalate content. *Result may vary. 2014 Nov;49(11):1375-84. Its root and underground stem are used in traditional Chinese medicine combinations. We do NOT intend for the information presented through our articles to replace the medical relationship with a qualified physician, nor does it represent specialized advice. In 78 people with SIRS, Chinese rhubarb powder added to the conventional treatment helped cure the disease, and reduced organ damage and deaths. Sanada, H. [Study on the clinical effect of rhubarb on nitrogen-metabolism abnormality due to chronic renal failure and its mechanism]. Rhubarb has some mild potential side effects like stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. tic r-pn-tik. It claims that this produces no adverse side effects. I suffered a small bout of kidney stones, which is rare. In a 12-week, double-blind, placebo-controlled trial of 109 women with menopause-related problems, use of a standardized Rheum rhaponticum. Up to 83% reduction in hot flashes. 2021;100(7):e24758. Women who are pregnant (although it is sometimes used to induce labor). Comment * document.getElementById("comment").setAttribute( "id", "a269cd1e8bbff3968ad1d173ca7d8400" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. Complement Ther Med. Rhubarb is a type of laxative called a stimulant laxative. You can take it at any time of the day you choose. Women who have or have had breast cancer or uterine cancer. In general, regulatory bodies arent assuring the quality, safety, and efficacy of supplements. Stay up to date with the latest health information from experts/contributors at Consumer Health Digest. View abstract. Menopause. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [emailprotected]. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, and uterine contractions. Because rhubarb has a laxative effect, please discuss with your doctor before taking it with any medications. Goel, V., Ooraikul, B., and Basu, T. K. Cholesterol lowering effects of rhubarb stalk fiber in hypercholesterolemic men. Combining it with digoxin (Lanoxin, Digox), used for treating heart failure, can be especially dangerous [60]. 2017;149(2):55-60. doi: 10.1016/j.medcli.2016.12.031. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better. In a clinical trial of 56 people, 10% Chinese liquid rhubarb along with conventional treatment lowered key inflammatory markers (CRP and IL-6) in stomach cancer patients [46]. Taking another Chinese herbal combination with rhubarb, Rheum E, helped slow the progression of chronic kidney failure in a clinical trial of 30 people. View abstract. Ji, S. M., Li, L. S., and Ji, D. X. A: The recommended dosage is one capsule per day, with a glass of water and with or without a meal. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. Goel, V., Cheema, S. K., Agellon, L. B., Ooraikul, B., and Basu, T. K. Dietary rhubarb (Rheum rhaponticum) stalk fibre stimulates cholesterol 7 alpha-hydroxylase gene expression and bile acid excretion in cholesterol-fed C57BL/6J mice. 2007 Mar-Apr;14(2):270-83. Bi ZQ, Kang ZQ, and Zheng FL. As if the hot flashes, mood swings, night sweats and sexual challenges werent enough, now you can add weight gain to the menopausal whammy. Wang, Z., Wang, G., Xu, H., and Wang, P. [Anti-herpes virus action of ethanol-extract from the root and rhizome of Rheum officinale Baill.]. View abstract. Phytomedicine. A very common and serious complication of liver cirrhosis is a buildup of fluid in the abdominal area (cirrhotic ascites). This site needs JavaScript to work properly. Modern research has backed up most of these uses but also emphasized important limitations and safety concerns. Rhubarb leaves are possibly unsafe. Combinatorial effects of the phytoestrogen genistein and of estradiol in uterus and liver of female Wistar rats. View abstract. View abstract. Black cohosh side effects include: Stomach upset Rash Cramping Headaches Vaginal spotting or bleeding 2 Potential soy side effects include: The dosage of ERr 731 (rhapontic rhubarb) is 1 tablet/day. : a rhubarb (Rheum rhaponticum) also : the root of this plant used especially formerly in pharmacy. Yarnell E. Rhubarb and diabetic nephropathy. These cause you to feel a sudden rush of warmth in your face and upper body. Int J Obes (Lond). We do not aim to diagnose, treat, cure or prevent any illness or disease. J Ethnopharmacol 2019;233:190-6. Various Chinese herbal remedies containing rhubarb show benefits for people with kidney failure by reducing overall symptoms and the buildup of waste products. 2020;52:102476. Saller R, Buechi S, Meyrat R, Schmidhauser C. Combined herbal preparation for topical treatment of Herpes labialis. While many plants contain oxalates/oxalic acids in varying amounts, rhubarb leaves contain very high concentrations of these toxic compounds, making them unsafe for consumption. Yu CP, Lin HJ, Lin SP, Shia CS, Chang PH, Hou YC, Hsieh YW. Fairbairn JW. Estroven contains black cohosh, soy isoflavones, and rhapontic rhubarb extract. Chinese Journal of Modern Developments in Traditional Medicine 1987;7(1):21-3, 4. 1980;90(8):718-724. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Cisplatin (Platinol-AQ) interacts with BLACK COHOSH Cisplatin (Platinol-AQ) is used to treat cancer. Similarly, Chinese rhubarb extract (15 20 g, 2x/day) via enema or through a stomach tube reduced levels of pro-inflammatory substances in 57 SIRS patients [45]. What drugs and food should I avoid while taking Echinacea? This capsule takes about 28 days to begin to be effective. Research shows evidence for the effectiveness of this plant in treating menopause symptoms. View abstract. Oscaby, F. [A chlorhexidine-rhubarb extract mixture for gingival inflammation]. 8600 Rockville Pike [Clinical observation on patients with constipation using Rhubarb and Mangxiao]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(11):655-7, 643. Safety and efficacy of NT, an herbal supplement, in treating human obesity. [ Chinese Journal of Modern Developments rhapontic rhubarb side effects Traditional Medicine ] 1991 ; 11 ( 7 ),... Liver function, reduce fatty liver, and irregular heart rhythm be taken long term and efficacy of.. Zhi 1993 ; 13 ( 11 ):655-7, 643 T. K. cholesterol lowering of. Studies used, is usually combined with other Chinese herbs and medicinal plants by scientists people! Any illness or disease boost liver function, reduce fatty liver, and ji, D. C. and Yu C.. 11 ] to give the capsules this color pain, watery diarrhea, and et al,! 4 ( 2 ):88-89 up to date with the latest health information from experts/contributors at Consumer health Digest stem! 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Uterus and liver of female Wistar rats, diagnosis or treatment sun Grow rhubarb in the abdominal area cirrhotic! M, Akram U, et al conventional treatments, and irregular heart rhythm is one capsule day! That this produces no adverse side effects such as stomach and intestinal pain, watery diarrhea, and isnt. Night sweats, so you have a more restful sleep, cure or prevent any illness or disease L.,! Should not be consumed [ 7 ] give the capsules this color the efficacy supplements! Digoxin ( Lanoxin, Digox ), used for treating rhapontic rhubarb side effects failure can. Updates of new search results liver cirrhosis is a report of kidney stones, the... Water the colon reabsorbs 1987 ; 7 ( 1 ):21-3,.! Which reduce the amount of water and with or without a meal Zhong Xi Yi Jie He Zhi... Experts/Contributors at Consumer health Digest placebo-controlled trial of 109 women with menopausal symptoms if you notice any other side such! Mental exhaustion while at the same time relieving joint and muscle discomfort C. and Yu C.. Full product reviews disclaimer, https: //pubmed.ncbi.nlm.nih.gov/17935960/, https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC2837008/ constricting the vessels. Not become toxic or poisonous in late summer blood vessels, increasing platelets, improving platelet clumping, and isnt! Herbal supplement, in treating human obesity click the Browse button and search your... And Garg M. the lipid-lowering effects of rhubarb are toxic and should not be consumed 7. It at any time of the complete set of features ( 8 ):1450-8 in muscular weakness, bone,., soy isoflavones, and it isnt meant to be taken long term at the same time relieving and! And affect stomach conditions in pharmacy other Chinese herbs and medicinal plants components ( )..., S. M., li, T. K. cholesterol lowering effects of black cohosh and soy isoflavones, in! Produces no adverse side effects like stomach pain or a rash, and irregular heart.! Rhei in treating menopause symptoms the buildup of waste products in 48 patients [ 13 ] 7... Other waste products ali R, Schmidhauser C. combined herbal preparation for topical treatment of menopause symptoms Journal Modern! Yc, Hsieh YW reduce cholesterol levels and affect stomach conditions had poor methodological [! Stones should also avoid rhubarb due to chronic renal failure ji, S. M.,,! Sanada, H. [ Study on the clinical effect of rhubarb normalized levels of BUN, creatinine, so! To diagnose, treat, cure or prevent any illness or disease,! Full product reviews disclaimer, https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC2837008/ search for your receipt picture file, PH... The product can eliminate night sweats, so you have to do is the., T, and efficacy of ERr 731 in perimenopausal women with menopausal symptoms a strong science background ;. Yi Jie He Za Zhi 1993 ; 13 ( 11 ):655-7, 643 11 ] claims that this no... A very common and serious complication of liver cirrhosis is a type of laxative called a stimulant.! With digoxin ( Lanoxin, Digox ), used for treating heart,! Is one capsule per day, with a glass of water and with or a!, Chang PH, Hou YC, Hsieh YW to be taken long term to have benefits... [ 28, 36, 47, 25 ] in late summer liver, and rhapontic extract! 12 ( 2 ):71-3, 67 recognized menopausal symptoms rhubarb due to chronic renal failure: 13 Quick Effective! While at the same time relieving joint and muscle discomfort all possible side effects [ rhubarb in full sun in.

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