Baikal skullcap might lower blood pressure. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. This will help them manage your care and keep you safe. Lin, C. C., Kuo, C. L., Lee, M. H., Lai, K. C., Lin, J. P., Yang, J. S., Yu, C. S., Lu, C. C., Chiang, J. H., Chueh, F. S., and Chung, J. G. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. Toxicol.Appl.Pharmacol 8-1-2011;254(3):221-228. View abstract. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. View abstract. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. 5-24-2006;105(3):346-351. Some medications are moved in and out of cells by pumps. View abstract. From: Polyphenols in Human Health and Disease, 2014. Konig J, Seithel A, Gradhand U, Fromm MF. Luo, X., Zhou, X., Su, P., and Zhu, W. [Effects of Scutellaria baicalensis stem-leaf total flavonoid on proliferation of vassel smooth muscle cells stimulated by high triglyceride blood serum]. Z. Biochim Biophys Acta 1999;1472:643-50. This herb has also given great results when used as a liver-protectant; therefore, there is no surety whether it is bad or good for humans. View abstract. The growing interest in skin lightening has recently renewed attention on the esthetic applications of Chinese herbal medicine. Therefore such people should avoid taking it to prevent serious side effects. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), and others. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. Phytother Res 2000;14:210-2. View abstract. View abstract. Studies in humans are quite limited. Keep in mind that natural products are not always necessarily safe and dosages can be important. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of. Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Wu X, Zhang H, Salmani JM, et al. Chamaecyparis Obtusa Leaf Extract: Scutellaria Baicalensis Root Extract: soothing, antioxidant, antimicrobial/ antibacterial, moisturizer/ humectant: goodie: Cinnamomum Cassia Bark Extract: Sodium Hyaluronate: skin-identical ingredient, moisturizer/ humectant Lam, T. L., Lam, M. L., Au, T. K., Ip, D. T., Ng, T. B., Fong, W. P., and Wan, D. C. A comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of Chinese medicinal herbs. Arjmandi BH, Ormsbee LT, Elam ML, et al. Onco Targets Ther 2016;9:2935-43. [Study of Scutellaria baicalensis and Baicalin against antimicrobial susceptibility of Helicobacter pylori strains in vitro]. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Talk with your healthcare provider before using this product if you are taking lithium. However, it is not known if the herb would exert similar effects by itself, and cases of hepatotoxicity with some supplements have been reported(18)(24). In vitro studies suggest that S. barbata has antibacterial(1), antioxidant(15), antimutagenic(2), and anticancer(3)(4)(5)(6)(7)(8)(10)(11)(12) properties. Clin Pharmacol Ther 2007;82:726-33. 2011;39(1):217-224. Planta Med 1995;61(2):150-153. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Biological properties of baicalein in cardiovascular system. The purpose of this study was to investigate whether SB exhibited anticancer activity in EGFR TKI-resistant lung cancer cells and to explore the underlying mechanism. Nontoxic; LD 50 is tested, none. Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. Cell Mol Biol Res 1993;39(2):119-124. View abstract. Ren S, Cao D., Yang J, and et al. WebSide Effects Precautions Interactions Dosing Reviews (4) Overview Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. Sonoda, M., Nishiyama, T., Matsukawa, Y., and Moriyasu, M. Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. 1-8-2007;245(1-2):269-274. Skullcap should not be used during pregnancy or breastfeeding. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. View abstract. Blach-Olszewska, Z., Jatczak, B., Rak, A., Lorenc, M., Gulanowski, B., Drobna, A., and Lamer-Zarawska, E. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. But there isn't enough information to know if this is an important interaction. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Common substitutions for Baikal skullcap in Chinese medicine include related plants whose scientific names are Scutellaria viscidula, Scutellaria amonea, and Scutellaria ikoninikovii. Tseng-Crank J, Sung S, Jia Q, and et al. Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Chen et C. Ling and Scutellaria baicalensis Georgi. Altern.Ther.Health Med. J Med Chem 10-21-2004;47(22):5555-5566. View abstract. (detailed description of each of the ratings). 2005 - 2023 WebMD LLC, an Internet Brands company. View abstract. Am J Physiol Endocrinol Metab. J Biomed.Sci 2011;18:14. 11-12-2009;126(2):320-331. Vopr.Onkol. Letter/Prescriber's Letter. J Ethnopharmacol 2005;98:295-300. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. vitamins, herbs, dietary supplements a-z listbaikal skullcap. Liu, G., Rajesh, N., Wang, X., Zhang, M., Wu, Q., Li, S., Chen, B., and Yao, S. Identification of flavonoids in the stems and leaves of Scutellaria baicalensis Georgi. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. Br J Pharmacol 2009;157:1410-18. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. View abstract. Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. J Ethnopharmacol. View abstract. Wang, G. F., Wu, Z. F., Wan, L., Wang, Q. T., and Chen, F. M. Influence of baicalin on the expression of receptor activator of nuclear factor-kappaB ligand in cultured human periodontal ligament cells. View abstract. Consult your Doctor if you are Pregnant and Breastfeeding. The root has been used in Chinese medicine for psychiatric disorders. Tell your healthcare providers about any dietary supplements youre taking, such as herbs, vitamins, minerals, and natural or home remedies. Wu, J. Y., Chung, K. T., Liu, Y. W., Lu, F. J., Tsai, R. S., Chen, C. H., and Chen, C. H. Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. Sheng, J. P., Chen, H. R., and Shen, L. [Comparative study on selenium and amino acids content in leaves of planted and wild Scutellaria baicalensis]. View abstract. View abstract. View abstract. Moreover, many safety tests are not done; therefore, the medicines effectiveness and benefits are not completely known. Krskova, Z., Martin, J., Pec, J., and Dusek, J. 2009;110(4):1276-1287. Visit the FDA MedWatch website or call 1-800-FDA-1088. View abstract. Liu, W., Mu, R., Nie, F. F., Yang, Y., Wang, J., Dai, Q. S., Lu, N., Qi, Q., Rong, J. J., Hu, R., Wang, X. T., You, Q. D., and Guo, Q. L. MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. Pharmacol.Res. Intern Med 2001;40:764-8. Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. There isn't enough reliable information to know what an appropriate dose of Baikal skullcap might be. Yimam, M., Zhao, Y., Ma, W., Jia, Q., Do, S. G., and Shin, J. H. 90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats. View abstract. Baikal skullcap might cause sleepiness and drowsiness. Neuroprotective effect of baicalein against MPTP neurotoxicity: Behavioral, biochemical and immunohistochemical profile. Kimura, Y., Matsushita, N., Yokoi-Hayashi, K., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation. View abstract. View abstract. Mol Carcinog. There is concern that it might cause extra bleeding during and after surgery. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. Wiad.Lek. Yang, D., Hu, H., Huang, S., Chaumont, J. P., and Millet, J. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Biol Pharm Bull 2004;27(10):1580-1583. Eye contact Rinse with water. Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia. View abstract. Lai, M. Y., Hsiu, S. L., Chen, C. C., Hou, Y. C., and Chao, P. D. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. Int J Antimicrob.Agents 2009;34(3):284-285. Planta Med 2000;66(8):694-698. Zhang S, Cheng Z, Huang B, and Li J. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. View abstract. Phytomedicine. J Ethnopharmacol 2005;98:295-300. View abstract. September 2012. 4-12-2011;134(3):884-891. Certain flavonoid components appear to have anticancer activity in vitro: wogonin caused G1 arrest, while baicalin and baicalein cause G2/M accumulation(2). View abstract. Hua Xi.Kou Qiang.Yi.Xue.Za Zhi 2006;24(2):131-134. View abstract. Vestn.Ross.Akad.Med Nauk 1995;(1):29-38. View abstract. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. J Chromatogr.B Analyt.Technol Biomed.Life Sci 4-15-2011;879(13-14):1023-1028. There are no known side effects of using scutellaria baicalensis root extract and it is considered gentle enough for sensitive skin types to use. Integr.Cancer Ther. View abstract. Ceska.Slov.Farm. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Lin YK, Yen HR, Wong WR, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Zhang S, Cheng Z, Huang B, and Li J. Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. No matter new buyer or old purchaser, We believe in long expression and trusted relationship for Scutellaria Baicalensis Root, Nootropics Modafinil, Herbal Extract Oil, Maca Extract Liquid, Hawthorn Extract Vs Hawthorn Berry. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. View abstract. Phytother.Res 2009;23(10):1415-1420. Hong, T., Jeong, M. L., Zahn, M., Fay, B. 2-1-2010;84(2):137-144. Taking Baikal skullcap along with diabetes medications might cause your blood sugar to go too low. WebSummary: As a traditional Chinese herbal medicine, Scutellaria baicalensis has shown significant effects on the treatment of various diseases, especially hepatitis, diarrhoea, vomiting and high blood pressure. Birth Defects Res B Dev.Reprod.Toxicol. Food Chem Toxicol. Cancer Lett. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. View abstract. Daugel'-Dauge, N. O., Durnev, A. D., Kulakova, A. V., Seredenin, S. B., and Velichkovskii, B. T. [Corpuscular mutagenesis and its prevention]. Life Sci 10-27-2000;67(23):2889-2896. Available at: https://www.fda.gov/food/alerts-advisories-safety-information/fda-alerts-consumers-about-potentially-life-threatening-health-problems-linked-limbrel. 9-7-2009;125(2):286-290. Journal of Dietary Supplements 2010;7:253. Scutellaria barbata is a perennial herb that is used along with other botanicals in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. Dosage: 39 g/day/adult. A traditional Chinese herbal medicine loaded with potent antioxidant and anti-inflammatoryflavonoids such as baicalin, baicalein, and wogonin. Pharmacogenomics of human OATP transporters. Phytother.Res 2003;17(6):640-644. View abstract. Baikal skullcap might change how these pumps work and change how much medication stays in the body. 4-26-2011;135(1):179-185. View abstract. View abstract. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. Herbal hepatoxicity from Chinese skullcap: A case report. View abstract. Involvement of p53 in oroxylin A-induced apoptosis in cancer cells. Clin Pharmacol Ther 2007;83:471-6. Baicalin is anti-inflammatory in cigarette smoke-induced inflammatory models in vivo and in vitro: A possible role for HDAC2 activity. Kang, T. H., Hong, B. N., Park, C., Kim, S. Y., and Park, R. Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss. December 19, 2017. View abstract. Do you know this herb by any other name ? We currently have no information for BAIKAL SKULLCAP overview. Typical doses (see individual product information): Dried herb: 1 to 2 g View abstract. Limit doses of American skullcap to no more than the package recommendation. Tong, R., Mehendale, S. R., Wang, C. Z., Shao, Z., and Yuan, C. S. Comparison of antioxidant effects of various Scutellaria baicalensis fractions and the potential role of catalase upregulation. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal. View abstract. Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. The effect of supplementation with Scutellaria baicalensis on hepatic function. Bacteriostatic activity of combined application of Galla chinensis, Scutellaria baicalensis and Rhizoma coptidis against MRSA in vitro. Scutellaria baicalensis root is a plant/plant extract used in some OTC (over-the-counter) products. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. This is especially relevant to macrophages and immune cells. J Ethnopharmacol. View abstract. Taking Baikal skullcap might decrease how well the body gets rid of lithium. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. View abstract. The dose of your diabetes medication might need to be changed. Taking Baikal skullcap with medications used to treat high blood pressure might cause blood pressure levels to go to low. Bull Exp Biol Med 2004;137(5):471-474. View abstract. 11-15-2009;171(1-3):508-513. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. However, low doses of baicalin upregulated expression of multiple angiogenic genes to increase cell proliferation in developing blood vessels, while high doses inhibited angiogenesis by inducing cell death, suggesting dose-dependent dual effects. Vopr.Onkol. J Ethnopharmacol. View abstract. 4-12-2011;134(3):884-891. Int J Cancer 9-10-2003;106(4):559-565. 2009;29(5):1286-1288. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. S. barbata is an herb found in Korea and southern China. Nat Prod Res 2008;22(16):1410-1412. View abstract. Biomed.Chromatogr. [Analysis of main flavonoids contents of Scutellaria baicalensis]. Pharmacogenomics of human OATP transporters. Side Effects Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. Li BQ, Fu T, Gong WH, et al. Numerous traditional uses of Scutellaria baicalensis have been confirmed by current investigations. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. 2004;23(8):874-878. In addition, it can reduce inflammation in the body can easily heal liver toxicity, and can detoxify the body. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. 2009;30(11):1505-1512. 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