2015 Jul 7;87(2):105-20. doi: 10.4081/aiua.2015.2.105. Staff. Potassium chloride and potassium citrate have similar names, so they should treat the same conditions, right? Not quite. While they are both supplements that contain potassium, the two actually have different uses, side effects and dosages, and cannot be substituted for each other.Potassium chloride is a mineral used to replenish potassium within our body. Medically reviewed by Sally Chao, MD. It contains only 16.69% potassium by mass. Both dosage regimens led to reductions in serum PINP concentration and urine NTX concentration, yet evidence of an effect was stronger with the lowest dose (median dose administered, 3,160 mg/day) rather than with the highest dose (median dose administered, 4,760 mg/day). 1994;23(2):359-377. 2012;4:2097-120. 1985 Sep;79(3):284-8. doi: 10.1016/0002-9343(85)90305-5. Physicians may recommend diet changes or the consumption of foods that are high in potassium before prescribing a supplement. Get answers from Nephrologists and top U.S. doctors, Our doctors evaluate, diagnose, prescribe, order lab tests, and recommend follow-up care. Two additional meta-analyses published in 2017 also confirmed a blood pressure-lowering effect of supplemental potassium. (PubMed), 37. Its formula is: c6h11ko7. Both potassium citrate and potassium gluconate may be used as food additives or supplements, but they have some slightly different applications. There is no evidence that potassium supplements are useful in the treatment of high blood pressure. Gastrointestinal symptoms are the most common side effects of potassium supplements, including nausea, vomiting, abdominal discomfort, and diarrhea. It helps maintain the water balance inside the cells and is essential in the transmission of nerve impulses. You may not copy, modify, distribute, display, transmit, perform, publish or sell any of the copyrightable material on this website. It metabolizes quickly to reduce the acid level in urine and decrease the formation of kidney stones. Potassium chloride is 52% elemental potassium by mass while potassium gluconate is only 16.7% elemental potassium by mass. Available for Android and iOS devices. As a consequence, median potassium intakes observed in apparently healthy people were used to set adequate intakes (AI) by age/life stage in the recent revision of the Dietary Reference Intakes (DRIs) for potassium. It is used to treat a kidney stone Examples of food products that may contain potassium citrate include some cheeses, margarines and jellies. Trinchieri A, Zanetti G, Curro A, Lizzano R. Effect of potential renal acid load of foods on calcium metabolism of renal calcium stone formers. Walker BR, Edwards CR. Your doctor may change the dose if needed. Video chat with a U.S. board-certified doctor 24/7 in a minute. A prolonged bout of vomiting or diarrhea can also cause hypokalemia. [Epub ahead of print]. DElia L, Barba G, Cappuccio FP, Strazzullo P. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies. N Engl J Med. MeSH Your body uses potassium to help your heart, muscles, kidneys, nerves and digestive system work properly. BMJ. Dietary potassium intake of 4.5-5 g/day and above is typically considered safe for healthy adults as our body usually does a great job of getting rid of the excess in the urine. Both potassium citrate and Both potassium supp: Citrate acts as a buffer/alkali in conditions with high acid (acidemia). Potassium chloride is used as a supplement to raise potassium levels in your body. Dietary protein and potassium, diet-dependent net acid load, and risk of incident kidney stones. Thank you. In 2016, the US Food and Drug Administration (FDA) required manufacturers to display potassium content of foods on the Nutrition Facts food label (48). health information, we will treat all of that information as protected health Food and Nutrition Board, Institute of Medicine. However, most people will not take more than 100 mEq a day. Dietary magnesium and potassium intakes and circulating magnesium are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the EPIC-Norfolk cohort study. Potassium citrate may also be used for other purposes other than those listed in this medication guide. By lowering the uric acid level, potassium citrate is helpful in preventing or treating gout and certain metabolic disorders resulting from kidney disease 3. WebPotassium Citrate and Potassium Gluconate Versus Potassium Chloride: Experimental Evaluation of Relative Intestinal Toxicity | JAMA | JAMA Network IN LATE 1964 a sudden increase in the occurrence of circumferential ulcerating, stenosing lesions of the small bowel was noted both in Europe and the United Sta [Skip to Navigation] There are a few different types including potassium chloride, potassium gluconate, and potassium citrate. Am I choosing an appropriate replacement? Outdated tetracycline antibiotics have been linked to electrolyte disturbances. Accessed 11/19/18. development of hypertension, particularly when salt (sodium) intake is high. Med Clin North Am. The richest sources of potassium are fruit and vegetables. We answer our latest question regarding the difference between dietary potassium from foods and potassium medication to treat hypokalemia (low potassium). Int J Cardiol. 22. (PubMed), 17. 2013;4(3):368s-377s. Halide lab. Pak CY, Fuller C, Sakhaee K, Preminger GM, Britton F. J Urol. However, most people will not take more than 100 mEq a day. It is used to treat a kidney stone condition called renal tubular acidosis. Natural Medicines. November 2016. DOI: 10.3390/nu4122097. doi: 10.1152/ajprenal.00116.2013. Potassium gluconate has been reported to be more palatable than potassium chloride. This site needs JavaScript to work properly. Linus Pauling Institute Mente A, O'Donnell M, Rangarajan S, et al. Taking too much potassium can cause serious side effects like heart arrhythmias. Distinguished Professor and Department Head Please check with the appropriate physician regarding health questions and concerns. There are a variety of other potassium salt medications available as well, such as potassium citrate and potassium gluconate, that are prescribed for different reasons, most notably to balance out our body acid-base levels. 2016 Nov-Dec;10(11-12):E347-E358. The amount of medicine that you take depends on the strength of the medicine. Potassium gives you energy. Created for people with ongoing healthcare needs but benefits everyone. Note Restricted to advanced placement science. Williams is a registered nurse with more than 35 years of experience and holds a Bachelor of Science degree in health-care administration. We'll first start with the main differences between the two. : Nuts, seeds, and whole-grain cereals (especially oats and barley): Lamisil Vs. Lotrimin: What Is The Difference? However, potassium citrate therapy should only be initiated under the supervision of a medical provider. J Nutr. Jackson SL, Cogswell ME, Zhao L, et al. 2010;4(2):79-89. Your doctor may change the dose if needed. Potassium citrate and potassium chloride. Which is better for summer heat? Would you like email updates of new search results? Increasing potassium intake to recommended levels (see Adequate Intake) by consuming a diet rich in fruit and vegetables can help lower blood pressure and may have additional benefits to health (see the article on Fruit and Vegetables). One milliequivalent (mEq) or one millimole (mmol) corresponds to about 39 mg of potassium. 2001;39 Suppl 2:33-36; discussion 36-37. 55. Potassium glycinate is glycine, monopotassium salt and its formula is c2h4kno2. Since your potassium gluconate supplement contains 550mg per pill, that equates to about 8.5 tablets. Potassium citrate forms white or transparent crystals, while potassium gluconate forms yellowish white granules. Gluconate formulations are common in over the counter formulations. Office of Dietary Supplements. Moreover, avoid these supplements if you: Interaction with alcohol is unknown, thus, stay on the safe side and avoid alcoholic beverages while using these supplements. Nutrients. Modern diets, which are high in sodium and low in potassium, are recognized as largely contributing to the high prevalence of hypertension (see the article on Sodium). Epub 2022 May 8. Jehle S, Hulter HN, Krapf R. Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial. 2018;53(5):184-195. Potassium gluconate is alkaline (compared to potassium chloride, which is acidic). . Connie Weaver, Ph.D. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Table 3 lists the classes of medications known to increase the risk of hyperkalemia (elevated serum potassium) in patients who also use potassium supplements (50, 51, 54). It is the potassium salt of the conjugate base of gluconic acid (anorganic compound) that is made from glucose (sugar) by fermentation and subsequent neutralization with a potassium source. Potassium chloride supplementation averted thiazide-induced hypokalemia and hypocitraturia without influencing hypocalciuric action of thiazide or urinary pH. I've been treated for multiple myeloma for 10 years. J Am Heart Assoc. (PubMed), 29. Centers for Disease Control and Prevention. The symptoms of hypokalemia are related to alterations in membrane potential and cellular metabolism (1). 2013;346:f1326. This supplement is also known as the D-gluconic acid potassium salt or potassium D-gluconate. Cogswell ME, Loria CM, Terry AL, et al. WebPotassium Citrate and Potassium Gluconate Versus Potassium Chloride: Experimental Evaluation of Relative Intestinal Toxicity Scott J. Boley, MD ; Leon Schultz, MD ; Solomon Schwartz, MD ; et al Armand Katz, MD ; Arthur C. Allen, MD Your doctor may prescribe potassium citrate if you have a mild urinary tract infection, such as cystitis. 2013;142(4):327-345. (PubMed), 35. All rights reserved. Dr. wrote Rx for potassium citrate? Potassium citrate and potassium gluconate versus potassium chloride. People with certain kidney related issues may benefit from taking potassium citrate vs the other versions, but that is something that needs to be discussed with a medical provider. Your body uses potassium to help your heart, muscles, kidneys, nerves and digestive system work properly. He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Suarez M, Youssef RF. June 26, 2018. Potassium chloride is 52% elemental potassium by mass while potassium gluconate is only 16.7% elemental potassium by mass. Their activity has been estimated to account for 20%-40% of the resting energy expenditure in a typical adult. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. 23 years experience. Potassium citrate may cause serious side effects. Created for people with ongoing healthcare needs but You may opt-out of email communications at any time by clicking on Adults and teenagers16 to 24 mEq a day, divided into two or three smaller doses during the day. Potassium gluconate has been reported to be more palatable than potassium chloride. email:[emailprotected], Chlorophyll and Metallo-Chlorophyll Derivatives, Healthcare Professional Continuing Education, 2015-2020 Dietary Guidelines for Americans, https://www.cdc.gov/bloodpressure/facts.htm, Potassium Intake of the US Population: What We Eat In America, NHANES 2009-2010, https://www.regulations.gov/document?D=FDA-2012-N-1210-0875, https://naturalmedicines.therapeuticresearch.com, Angiotensin converting enzyme (ACE) inhibitors, captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), ramipril (Altace), Losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), candesartan (Atacand), Trimethoprim-sulfamethoxazole, pentamidine, Nonsteroidal anti-inflammatory agents (NSAID), spironolactone (Aldactone), triamterene (Dyrenium), amiloride (Midamor), amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), tobramycin (Nebcyn), streptomycin, amphotericin B (Abelcet, Amphotec, AmBisome, Amphocin, Fungizone), fluconazole (Diflucan), albuterol (Salbutamol, Ventolin), bitolterol (Tornalate), metaproterenol (Alupent), methylxanthines (e.g., theophylline), sodium polystyrene sulfonate, sodium phosphates, caffeine, Potassium is considered to be a "nutrient of public health concern" according to the 2015-2020 Dietary Guidelines for Americans since its underconsumption in the US population is associated with adverse health effects (. If you miss a dose of this medicine, take it as soon as possible. Because fruit and vegetables are rich in both potassium and precursors to bicarbonate ions, increasing their consumption might help reduce the net acid content of the diet and preserve calcium in bones, which might otherwise be mobilized to maintain normal pH (see the article on Fruit and Vegetables). 2016;5(10). The balance of potassium and sodium is critical for normal cell functioning. Your doctor may change the dose if needed. If you are a Mayo Clinic patient, this could Morris RC, Jr., Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A. The solution should be well mixed into water or juice. The Linus Pauling Institute's Micronutrient Information Center provides scientific information on the health aspects of dietary factors and supplements, food, and beverages for the general public. Please enable it to take advantage of the complete set of features! WebPotassium citrate is an alkalizing agent. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. By using our website, you consent to our use of cookies. WebThe effectiveness of potassium citrate as a potassium supplement was compared to that of potassium chloride in 13 patients with calcium nephrolithiasis treated with thiazide. 1994;330(25):1776-1781. WebPotassium citrate and potassium gluconate versus potassium chloride. Potassium/Professional Monograph/Nutrient Depletion. Epub 2018 Nov 26. Potassium is an electrolyte, which means that it disconnects into ions and can conduct electricity. Averted thiazide-induced hypokalemia and hypocitraturia without influencing hypocalciuric action of thiazide or urinary pH into water or juice and... Chloride, which is acidic ), abdominal discomfort, and cardiovascular a... 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